Appetite Suppressant 101

Weight loss is a common goal for millions of adults. Despite millions making the decision to lose fat, few achieve it, and even fewer maintain those results. One of the main reasons is due to feeling hungry.

Including enough protein, fiber, and healthy fats in your meals can help keep you feeling satisfied, even while dieting, but nevertheless, there will be times when you feel the desire to eat more.

Having a natural option to help hunger in check can be a real benefit in these moments.

Say hello to 1UP Appetite Suppressant!

Benefits of 1UP Appetite Suppressant

• Supports Reduced Appetite and Reduced Cravings
• Supports Increased Fullness
• Supports Improved Mood
• Supports Healthy Blood Sugar

1UP Appetite Suppressant Ingredients

1UP Appetite Suppressant is the culmination of natural appetite and weight loss support. Every serving contains research-backed ingredients, including Glucomannan, Caralluma Fimbriata, and CapsiMax, to help you stay on track, keep hunger in check, and achieve your goals!

Glucomannan (1,500mg)

Fiber plays a key role in digestive health, regularity, and appetite support. In fact, research shows that fiber helps to reduce appetite as well as food intake.[1]

However, significant portions of the population don’t regularly meet the recommended fiber intakes (14 grams per 1,000 calories eaten).

Dietary fiber is naturally abundant in plant foods, including fruits, veggies, whole grains, nuts, seeds and legumes. It’s also present in supplements, including 1UP Fiber Plus.

Glucomannan is a water-soluble, fermentable fiber. It's a component of hemicellulose -- a polysaccharide found in plant cell walls. One of the big upsides to glucomannan is that it is incredibly viscous, making it particularly beneficial for weight loss. This means it helps delay stomach emptying, which contributes to increased satiety.[2]

Research also shows that it can help reduce bodyweight and improve certain markers of cardiometabolic health, including total cholesterol, LDL (bad) cholesterol, triglycerides, and fasting blood glucose.[3,4]

Caralluma Fimbriata (350mg)

Caralluma fimbriata is an Indian edible cactus widely used in traditional medicine as an appetite suppressant and “famine food” (likely due to its hunger-suppressing properties).[5]

Early research in overweight found that caralluma may “...suppress appetite, and reduce waist circumference when compared to placebo over a 2 month period.”[6]

Other studies indicate that supplementing with caralluma may significantly reduce calorie intake from baseline compared to placebo (245 cal vs 15.8 cal respectively p < 0.01).[7] This reduced calorie intake was also found to lead to a reduction in waist circumference of 2.7cm compared to an increase of 0.3 cm in the placebo group.[7]

5-HTP (300mg)

5-HTP is the direct precursor to serotonin -- a neurotransmitter, most commonly associated with feelings of well-being. Neuroimaging studies have found that obesity is often associated with decreased serotonin signaling.[8]

Other studies note that serotonin administration helps reduce food intake.[9] A systematic review and meta-analysis appearing in The Lancet also state that medications that stimulate serotonin are effective aids for weight reduction.[10]

As a direct precursor to serotonin, 5-HTP helps naturally increase serotonin levels. Studies document that 5-HTP supplementation may help curb cravings and reduce appetite as well as inhibit the intake of calories from carbohydrates.[11,12,13]

CapsiMax (45mg)

Capsimax is the industry-leading patented red chili pepper extract on the market. One that provides a terrific stimulant-free weight management solution without the GI upset common to generic red pepper supplements.

Standardized for capsaicin (the pungent alkaloid in Chile peppers that give them their “bite”), Capsimax has been shown in studies to help boost metabolism, help burn fat and curb appetite.[14]

Specifically, Capsimax has shown to help individuals burn at least 6% more calories over a 4-hour period. And, in overweight individuals, Capsimax was able to increase metabolism and support burning of nearly 130 calories over a 4-hour period.[15]

Perhaps most surprisingly, supplementation with capsaicin has been found to increase strength! In fact, individuals takingcapsaicin increased upper body strength by 13.4% over a 6-week period compared to just a 5.6% increase when using placebo.[16]

Basically, CapsiMax offers 3 benefits in 1! It not only helps reduce appetite and increase daily energy expenditure (both of which support weight loss), it also helps improve workout performance!

Chromium (500mcg)

Chromium is a trace mineral that potentiates insulin action, which enhances glucose uptake by the cells. Proper insulin function is critical to nutrient partitioning, energy production, and cardiometabolic health. It’s also necessary for increased energy expenditure and workout performance.[17]

Intense exercise increases your body’s micronutrient needs, including chromium. This can be met through eating the right foods and/or using the right supplements.

How to Use 1UP Appetite Suppressant

For best results, we suggest taking four (4) capsules of 1UP Appetite Suppressant 1 hour before a meal in the AM or PM to curb appetite cravings.

For added weight loss support, 1UP Appetite Suppressant can be combined with our thermogenic weight loss aids, Make Her Lean Max or Pro Ripped Max.

References

1. Wanders AJ, van den Borne JJ, de Graaf C, Hulshof T, Jonathan MC, Kristensen M, Mars M, Schols HA, Feskens EJ.Effects of dietary fibre on subjective appetite, energy intake and body weight: a systematic review of randomized controlled trialsc. Obes Rev. 2011 Sep;12(9):724-39. doi: 10.1111/j.1467-789X.2011.00895.x. Epub 2011 Jun 16. PMID: 21676152.
2. Howarth NC, Saltzman E, Roberts SB. Dietary fiber and weight regulation. Nutr Rev. 2001 May;59(5):129-39. doi: 10.1111/j.1753-4887.2001.tb07001.x. PMID: 11396693.
3. Sood N, Baker WL, Coleman CI. Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis. Am J Clin Nutr. 2008 Oct;88(4):1167-75. doi: 10.1093/ajcn/88.4.1167. PMID: 18842808.
4. Walsh DE, Yaghoubian V, Behforooz A. Effect of glucomannan on obese patients: a clinical study. Int J Obes. 1984;8(4):289-93. PMID: 6096282.
5. Caralluma fimbriata – Caralluma-Flowers of India. [Last assessed on 2013 Oct 12]. Available from:http://www.flowersofindia.net/catalog/slides/Caralluma.html
6. Kuriyan R, Raj T, Srinivas SK, Vaz M, Rajendran R, Kurpad AV. Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women. Appetite. 2007 May;48(3):338-44. doi: 10.1016/j.appet.2006.09.013. Epub 2006 Nov 13. PMID: 17097761.
7. Rao, A., Briskey, D., dos Reis, C. et al. The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults. Sci Rep 11, 6791 (2021). https://doi.org/10.1038/s41598-021-86108-2
8. van Galen KA, Ter Horst KW, Booij J, la Fleur SE, Serlie MJ. The role of central dopamine and serotonin in human obesity: lessons learned from molecular neuroimaging studies. Metabolism. 2018;85:325‐339.
9. Fletcher PJ, Burton MJ. Microstructural analysis of the anorectic action of peripherally administered 5‐HT. Pharmacol Biochem Behav. 1986;24(4):1133‐1136.
10. Shi, Q., Wang, Y., Hao, Q., Vandvik, P. O., Guyatt, G., Li, J., Chen, Z., Xu, S., Shen, Y., Ge, L., Sun, F., Li, L., Yu, J., Nong, K., Zou, X., Zhu, S., Wang, C., Zhang, S., Qiao, Z., … Li, S. (2021). Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials. The Lancet. https://doi.org/10.1016/S0140-6736(21)01640-8
11. Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998 Aug;3(4):271-80. PMID: 9727088.
12. Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006 Jul 20;51(2):239-49. doi: 10.1016/j.neuron.2006.06.004. PMID: 16846858.
13. Cangiano C, Laviano A, Del Ben M, Preziosa I, Angelico F, Cascino A, Rossi-Fanelli F. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int J Obes Relat Metab Disord. 1998 Jul;22(7):648-54. doi: 10.1038/sj.ijo.0800642. PMID: 9705024.
14. Szallasi A. Capsaicin for Weight Control: "Exercise in a Pill" (or Just Another Fad)? Pharmaceuticals (Basel). 2022 Jul 11;15(7):851. doi: 10.3390/ph15070851. PMID: 35890150; PMCID: PMC9316879.
15. https://www.sciencedirect.com/science/article/pii/S2475299123110328
16. Silva V.E.L.D.M.E., Cholewa J.M., Jäger R., Zanchi N.E., de Freitas M.C., de Moura R.C., Barros E.M.L., Antunes B.M., Caperuto E.C., Ribeiro S.L.G., et al. Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: A randomized, placebo-controlled and double-blind study. J. Int. Soc. Sports Nutr. 2021;18:50. doi: 10.1186/s12970-021-00446-0.
17. Lukaski HC. Magnesium, zinc, and chromium nutriture and physical activity. Am J Clin Nutr. 2000 Aug;72(2 Suppl):585S-93S. doi: 10.1093/ajcn/72.2.585S. PMID: 10919964.