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1UP Joint Health Plus 101

Joint health.


It’s not as sexy of a topic or supplement category as, say, pre-workout supplements, protein powders, or weight loss aids. However, if your joints aren’t operating smoothly, your ability to exercise consistently, let alone get the results you’re seeking, is severely compromised.


Given just how important joint health is, we’ve created a convenient, one-a-day joint health supplement solution in 1UP Joint Health Plus.


Benefits of 1UP Joint Health Plus

  • Supports healthy joints & tendons
  • Supports healthy bones
  • Supports motion & mobility
  • Supports joint comfort
  • No Deceptive Proprietary Blends


1UP Joint Health Plus Ingredients


NEM (Natural Eggshell Membrane)


Natural Eggshell Membrane is a collection of naturally occurring glycosaminoglycans, proteins, and other key nutrients, including:


  • Type I Collagen
  • Glucosamine
  • Chondroitin
  • Hyaluronic acid


These nutrients provide essential buildings that support your body’s ability to maintain healthy joint and connective tissues. NEM may also help to reduce pain and stiffness.


Human studies indicate that NEM supplementation may offer benefits in pain reduction both over the short-term (in as little as seven days) as well as with continual use (30 days).[1,2,3]


More recent research suggests that NEM supplementation may help reduce feelings of discomfort and improve daily functioning.[4]




Turmeric (Curcuma longa) is an important Ayurvedic herb that’s widely recognized for its antioxidant and anti-inflammatory properties.[5] It comes as little surprise then that curcumin-based supplements have gained popularity with individuals seeking a natural means to support healthy joints.


While turmeric contains a vast array of bioactive compounds, the primary one studied by researchers is curcumin. Research has demonstrated that curcumin supplementation favorably influences a variety of signaling pathways and mediators, which may help reduce joint pain, promote a healthy inflammatory response, and improve joint function.[6,7]



KollaGen II-xs


Type II Collagen is a major component of joint cartilage. While our bodies can naturally produce collagen, this ability declines with age. On top of that, our collective dietary habits don’t contain a lot of collagen-rich foods.


KollaGen II-xs provides a source of bioavailable type II collagen that supports joint comfort and function.[8]


Researcher demonstrates that KollaGen II-xs is readily absorbed by the body, accumulates in cartilage, and stimulates chondrocyte metabolism. This results in superior joint health support.




Andrographolide is a fascinating phytochemical found in the leaves ofandrographis paniculata. Specifically, andrographolide has been noted to interfere specifically with NFkB, which helps to reduce the expression of several proinflammatory genes, including COX-2, IL-6, IL-1ß.[9]


Human studies note that supplementing with ParActin may help reduce in pain, stiffness, and fatigue while improving function.[9]


Previous studies note that supplementation with andrographis paniculata extract also was found to help reduce stiffness, fatigue, and pain in adults with rheumatoid arthritis.[10]


Boswellia Serrata Extract


Boswellia (aka Indian Frankincense) extract has been used for centuries in traditional medicine for inflammation as well as a number of other conditions.


Researchers have identified a family of phytochemicals known as boswellic acids that are responsible for Boswellia's soothing qualities. Specifically, boswellic acids support reductions in inflammatory pathways, decreases in pro-inflammatory mediators, and reductions in the levels of matrix protein-degrading enzymes in the synovial fluid in the joints, thus reducing damage to cartilage in patients with osteoarthritis. Collectively, these functions help to reduce pain and swelling while increasing flexibility and motility.


Scientific research indicates that Boswellia Serrata’s anti-inflammatory activities may help reduce feelings of joint pain as well as improve joint function and mobility.[11,12]


However, not all Boswellia Serrata supplements are equal as there are many different standardizations available. Moreover, many cheap boswellia supplements don’t include sufficient levels of active ingredients to deliver results.


This is why 1UP Joint Health Plus includes a premium-grade boswellia extract standardized to 65% boswellic acids.


Ginger Root


A relative of turmeric, ginger is another popular cooking spice renowned for its soothing properties. The root contains multiple bioactives, including gingerols, shogaols, zingerone, and paradol, which have been found to offer anti-inflammatory effects by inhibiting[13]:


  • COX-1 and COX-2
  • nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)
  • 5-lipoxygenase (5-LOX)


Additionally, a 2015 research review documented that ginger supplementation may reduce to pain from eccentric resistance exercise and prolonged running.[14] This means that ginger may also help to promote post-workout recovery, thereby allowing you to train more frequently and get better results faster!




BioPerine is the industry-standard black pepper extract frequently included in a wide variety of dietary supplements to improve the absorption and effectiveness of nutraceuticals. Piperine (the active component of BioPerine) does this by slowing the breakdown of certain nutrients in the body, which allows them to survive longer in the digestive tract and offer greater benefit.


Piperine is also known to possess anti-inflammatory properties, which may further help promote healthy joint function and joint comfort.


In fact, studies have demonstrated that a combination of turmeric + ginger + black pepper (all three of which are included in 1UP Joint Health Plus) may improve the prostaglandin E2 (PGE2) levels in patients with chronic knee osteoarthritis similar to common OTC options.[15]




What is 1UP Joint Health Plus?


1UP Joint Health Plus is a premium-quality, once-a-day joint support supplement designed to help support optimal joint function and mobility as well as promote healthy cartilage and connective tissues.


Why Should I Take 1UP Joint Health Plus?


It doesn’t matter if you’re a high-level athlete, personal trainer, gym rat, couch potato, or casual fitness enthusiast, the health of your joints should be paramount.


In other words, joint health should be a major priority for you, regardless of your workout routine and competition aspirations. Your joints are involved in literally every movement you do throughout the day.


Even with proper diet, exercise, and rest, Father Time takes its toll -- cartilage wears down, inflammation balloons, and the body can’t recover as well as it once did (all the more so if you’re training intensely multiple days per week).


1UP Joint Health Plus provides a convenient and formidable option to nourishing your joints day in and day out.


Who Should Take 1UP Joint Health Plus?


1UP Joint Health Plus is for every fitness enthusiast -- male or female, young or old, competitive athlete, weekend warrior, or couch potato.


No matter what your goal -- building muscle, losing fat, or improving performance, joint health is critical not only to your ability to perform well in your workouts but also to go through your daily tasks pain-free.


When Should I Take 1UP Joint Health Plus?


1UP Joint Health Plus is best taken once daily with a meal of your choice. It may also be divided into two 2-capsule servings (one with breakfast and one with dinner).


Keep in mind that when you take Joint Health Plus isn't as important taking it consistently to get the maximum benefits.



  1. Ruff KJ, DeVore DP, Leu MD, Robinson MA. Eggshell membrane: a possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies. Clin Interv Aging. 2009;4:235-240. doi:10.2147/cia.s5797
  2. Danesch U, Seybold M, Rittinghausen R, Treibel W, Bitterlich N: NEM® brand eggshell membrane effective in the treatment of pain associated with knee and hip osteoarthritis: Results from a six center, open label German clinical study. J Arthritis 2014;3:136
  3. Brunello E, Masini A: NEM® brand eggshell membrane effective in the treatment of pain and stiffness associated with osteoarthritis of the knee in an Italian study population. Int J Clin Med 2016;7:169–175.
  4. Kiers, J. L., & Bult, J. H. F. (2020). Mildly Processed Natural Eggshell Membrane Alleviates Joint Pain Associated with Osteoarthritis of the Knee: A Randomized Double-Blind Placebo-Controlled Study. Journal of Medicinal Food, 24(3), 292–298. https://doi.org/10.1089/jmf.2020.0034
  5. Paultre K, Cade W, Hernandez D, Reynolds J, Greif D, Best TM. Therapeutic effects of turmeric or curcumin extract on pain and function for individuals with knee osteoarthritis: a systematic review. BMJ Open Sport Exerc Med. 2021 Jan 13;7(1):e000935. doi: 10.1136/bmjsem-2020-000935. PMID: 33500785; PMCID: PMC7812094.
  6. Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2016;19(8):717-729. doi:10.1089/jmf.2016.3705
  7. Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H. Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial. Front Immunol. 2022 Jul 22;13:891822. doi: 10.3389/fimmu.2022.891822. PMID: 35935936; PMCID: PMC9353077.
  8. BS Bagatela, AP Lopes, FL Affonso Fonseca, S Morton, J Gu, FF Perazzo. A 30-day clinical investigation of the safety and efficacy of kollaGen II-xs, a new avian sternal collagen type II hydrolysate. HealthMed. 1840-2291 e-ISSN 1986-8103. 12 Aug 2016
  9. Hancke, J. L., Srivastav, S., Cáceres, D. D., & Burgos, R. A. (2019). A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis. Phytotherapy Research. doi:10.1002/ptr.6339
  10. Burgos, R.A., Hancke, J.L., Bertoglio, J.C. et al. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clin Rheumatol 28, 931–946 (2009). https://doi.org/10.1007/s10067-009-1180-5
  11. Kimmatkar, N., Thawani, V., Hingorani, L., & Khiyani, R. (2003). Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – A randomized double blind placebo controlled trial. Phytomedicine, 10(1), 3–7. https://doi.org/https://doi.org/10.1078/094471103321648593
  12. Karlapudi V, Sunkara KB, Konda PR, Sarma KV, Rokkam MP. Efficacy and Safety of Aflapin®, a Novel Boswellia Serrata Extract, in the Treatment of Osteoarthritis of the Knee: A Short-Term 30-Day Randomized, Double-Blind, Placebo-Controlled Clinical Study. J Am Nutr Assoc. 2023 Feb;42(2):159-168. doi: 10.1080/07315724.2021.2014370. Epub 2022 Feb 15. PMID: 35512759.
  13. Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2016;19(8):717-729. doi:10.1089/jmf.2016.3705
  14. Wilson, P. B. (2015). Ginger (Zingiber officinale) as an Analgesic and Ergogenic Aid in Sport. Journal of Strength and Conditioning Research, 29(10), 2980–2995. doi:10.1519/jsc.0000000000001098
  15. Heidari-Beni M, Moravejolahkami AR, Gorgian P, Askari G, Tarrahi MJ, Bahreini-Esfahani N. Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial. Phytother Res. 2020 Aug;34(8):2067-2073. doi: 10.1002/ptr.6671. Epub 2020 Mar 16. PMID: 32180294.

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